Lion's Mane
Cognitive Balance | Mental Clarity | Nootropic
Triple-extracted Lion’s Mane in liquid form. Formulated for adults seeking to incorporate nature’s most studied compounds - traditionally associated with mental clarity, memory, and cognitive resilience.
EU-Certified Organic | Made in France | Lab-Tested
Extracted on Fresh Mushrooms | No Fillers | 100% Natural Formulation
- Regular price
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€99,00 - Regular price
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€109,50 - Sale price
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€99,00
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1. For You ?
Embraced by high-performers and mindful individuals who choose natural routines to stay sharp, focused, and mentally present.
Lion’s Mane is valued by those who seek clarity today and mental strength tomorrow.
Whether navigating demanding days or thinking ahead about cognitive aging, it’s a natural choice for those who care deeply about long-term focus and resilience.
2. Composition
Organic Lion's Mane - Hericium erinaceus - (Liquid Extract)
- 100% Organically Grown - Certified by Ecocert (EU Agriculture)
- Fruiting Body (100%)
- Mushroom Origin: Belgium (BE)
Other Ingredients: Purified Water, Organic Ethanol (20-24%)**
*Over 360 naturally occurring bioactive compounds have been documented in Lion's Mane, including:
- Hericenones (Benzaldehydes)
- Erinacines (Diterpenoids)
- β-glucan (Polysaccharides)
- Sterols
- Antioxidants (Hericene)
*Source: PubChem - Hericium erinaceus - Natural - Products
**Note: Ethanol is used as a solvent to extract and stabilize bioactive compounds and enhance product bioavailability.
3. Independent Studies
1. Long-Term Study on Cognitive Function in Aging: A 2020 placebo-controlled study evaluated the use of Lion’s Mane extract over 49 weeks in adults experiencing age-related cognitive decline. Researchers recorded differences in test scores between groups, positioning Lion’s Mane as a compound of interest in cognitive aging research. Link to Study : Front Aging Neurosci. 2020
2. Neurogenesis and Regeneration in Nerve Injury: Animal studies have explored Lion’s Mane’s role in promoting nerve regeneration, showing increased myelination and axonal regrowth. Link to Study : Behav Neurol. 2018.
3. Lion’s Mane and Task Performance in Healthy Adults : A double-blind, placebo-controlled pilot study explored the effects of Lion’s Mane supplementation over 28 days in healthy adults aged 18–45. Researchers observed differences in task response speed shortly after intake, as well as a trend toward reduced self-reported stress after sustained use. Link to Study : Nutrients. 2023
4. Neurotrophic properties & exploration of Nerve Growth Factor (NGF) Stimulation : Research has investigated how compounds in Lion’s Mane, particularly hericenones and erinacines, may stimulate nerve growth factor (NGF) synthesis in cells. Link to Study : Int J Med Mushrooms - 2013.
5. Exploratory Research on Gut and Immune Activity in Animal Models : An animal study examined the effects of Lion’s Mane polysaccharides on intestinal immune activity in mice. Researchers observed changes in gut-associated immune markers and microbiota composition after supplementation. These findings contribute to early-stage research investigating the relationship between functional mushrooms, gut ecosystems, and immune response. Link to Study : Int J Biol Macromol. 2017
For more insights, click here or visit the Scientific Resources section below on this page.
These studies are exploratory and do not constitute health claims. They are displayed here for educational purposes only. Lion’s Mane is not intended to diagnose, treat, or prevent any disease.
4. Transparency & Lab Analysis
From raw mushroom to final drop, we oversee every step in our own lab. No outsourcing, no shortcuts. Each batch is lab-tested for purity and screened for pesticides, heavy metals, and microbial residues. We use only glass and stainless steel to eliminate the risk of microplastic contamination.
We’re one of the few producers in this industry to go this far, controlling every detail from extraction to bottling to ensure unmatched quality and safety.
Lion’s Mane’s Most Studied Natural Compounds
Erinacines
Hericenones
Beta-Glucans
Our interest in extracting Lion’s Mane began by deep-diving into 24+ publications*.
What is Lion's Mane ?
Lion’s Mane (Hericium erinaceus) is an edible and functional mushroom traditionally used across Asia and increasingly studied for its potential role in cognitive health. Its name comes from its distinctive appearance: white, cascading spines that resemble a lion’s mane.
It naturally contains a variety of bioactive compounds, including hericenones, erinacines, and β-glucans, which are currently being studied for their potential roles in supporting the nervous system, promoting neurogenesis, and offering antioxidant properties.*
These compounds have been the focus of over hundreds of scientific publications, exploring their connection to nerve growth factor (NGF) stimulation, neuroprotective activity, and oxidative stress resistance in preclinical studies.*
Explore our TriExtract formula, combining three organic mushroom extracts : Lion’s Mane, Reishi, and Chaga for all-in-one daily support.
Who is it for?
Our Lion’s Mane extract adresses :
Adults 50+
Seeking to support mental clarity, alertness and long-term cognitive balance as part of a nutrition routine to prevent signs of mental fatigue.
High-performers
Entrepreneurs, researchers, students, and creatives who aim to stay mentally present, focused, and resilient during long hours of cognitively demanding work.
Why ?
Research shows that brain volume and weight begin to decline by about 5% per decade after age 40, with this rate potentially accelerating beyond age 70.*
This has contributed to growing interest in healthy aging routines by optimizing nutrition and incorporating natural compounds, such as those found in Lion's Mane, into daily wellness routines.
*Source : Aging and the brain - PMC
*Scientific Ressources
- MSKCC - Integrative Medicine database - Lion's Mane
- Khan MA, Tania M, Liu R, Rahman MM. Hericium erinaceus: an edible mushroom with medicinal values. J Complement Integr Med. May 24 2013;10doi:10.1515/jcim-2013-0001
- Tsai-Teng T, Chin-Chu C, Li-Ya L, et al. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice. J Biomed Sci. Jun 27 2016;23(1):49. doi:10.1186/s12929-016-0266-z
- Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N. Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Biomed Res. Feb 2011;32(1):67-72. doi:10.2220/biomedres.32.67
- Li Y, Zhang G, Ng TB, Wang H. A novel lectin with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from dried fruiting bodies of the monkey head mushroom Hericium erinaceum. J Biomed Biotechnol. 2010;2010:716515. doi:10.1155/2010/716515
- Abdulla MA, Fard AA, Sabaratnam V, et al. Potential activity of aqueous extract of culinary-medicinal Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats. Int J Med Mushrooms. 2011;13(1):33-9. doi:10.1615/intjmedmushr.v13.i1.50
- Wang M, Konishi T, Gao Y, Xu D, Gao Q. Anti-Gastric Ulcer Activity of Polysaccharide Fraction Isolated from Mycelium Culture of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes). Int J Med Mushrooms. 2015;17(11):1055-60. doi:10.1615/intjmedmushrooms.v17.i11.50
- Vigna L, Morelli F, Agnelli GM, et al. Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Evid Based Complement Alternat Med. 2019;2019:7861297. doi:10.1155/2019/7861297
- Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. Mar 2009;23(3):367-72. doi:10.1002/ptr.2634
- Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomed Res. 2019;40(4):125-131. doi:10.2220/biomedres.40.125
- Li IC, Chang HH, Lin CH, et al. Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front Aging Neurosci. 2020;12:155. doi:10.3389/fnagi.2020.00155
- Nagano M, Shimizu K, Kondo R, et al. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. Aug 2010;31(4):231-7. doi:10.2220/biomedres.31.231
- Docherty S, Doughty FL, Smith EF. The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients. Nov 20 2023;15(22)doi:10.3390/nu15224842
- Grozier CD, Alves VA, Killen LG, Simpson JD, O’Neal EK, Waldman HS. Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition. Int J Exerc Sci. 2022;15(2):1366-1380.
- Li W, Zhou W, Kim EJ, Shim SH, Kang HK, Kim YH. Isolation and identification of aromatic compounds in Lion’s Mane Mushroom and their anticancer activities. Food Chem. Mar 1 2015;170:336-42. doi:10.1016/j.foodchem.2014.08.078
- Wang M, Zhang Y, Xiao X, Xu D, Gao Y, Gao Q. A Polysaccharide Isolated from Mycelia of the Lion’s Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Induced Apoptosis in Precancerous Human Gastric Cells. Int J Med Mushrooms. 2017;19(12):1053-1060. doi:10.1615/IntJMedMushrooms.2017024975
- Kim SP, Nam SH, Friedman M. Hericium erinaceus (Lion’s Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice. J Agric Food Chem. May 22 2013;61(20):4898-904. doi:10.1021/jf400916c
- Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. J Agric Food Chem. Aug 19 2015;63(32):7108-23. doi:10.1021/acs.jafc.5b02914
- Hu JH, Li IC, Lin TW, et al. Absolute Bioavailability, Tissue Distribution, and Excretion of Erinacine S in Hericium erinaceus Mycelia. Molecules. Apr 24 2019;24(8)doi:10.3390/molecules24081624
- Zhang CC, Yin X, Cao CY, Wei J, Zhang Q, Gao JM. Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells. Bioorg Med Chem Lett. Nov 15 2015;25(22):5078-82. doi:10.1016/j.bmcl.2015.10.016
- Trovato A, Siracusa R, Di Paola R, et al. Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis. Immun Ageing. 2016;13:23. doi:10.1186/s12979-016-0078-8
- Wang LY, Huang CS, Chen YH, Chen CC, Chen CC, Chuang CH. Anti-Inflammatory Effect of Erinacine C on NO Production Through Down-Regulation of NF-κB and Activation of Nrf2-Mediated HO-1 in BV2 Microglial Cells Treated with LPS. Molecules. Sep 12 2019;24(18)doi:10.3390/molecules24183317
- Martínez-Mármol R, Chai Y, Conroy JN, et al. Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory. J Neurochem. Jun 2023;165(6):791-808. doi:10.1111/jnc.15767
- Li IC, Lee LY, Tzeng TT, et al. Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines. Behav Neurol. 2018;2018:5802634. doi:10.1155/2018/5802634
- Xie XQ, Geng Y, Guan Q, et al. Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study. Nutrients. Mar 21 2021;13(3)doi:10.3390/nu13031008
Most Lion's Mane Supplements Stop at Standard. We Don’t.
Every detail, from sourcing to formulationn is considered to ensure that when you choose Polyextract, you’re choosing an extract that goes far beyond industry standards.
No shortcuts. No compromises. Just premium quality, start to finish.
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Vegan
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Gluten-Free
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Certified Organic
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No Animal Testing
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No-Binders
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Allergen-Free
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100% EU Ingredients
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GMO-Free
Making each dose work harder for you.
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Selection
The concentration of active compounds in Lion’s Mane depends heavily on how the mushroom is grown.
That’s why we’ve established a direct partnership with our organic mushroom farmer in Belgium allowing us to oversee everything from the strain selection and substrate composition to the harvest timing and delivery conditions.
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Innovation
We spent 2 years developing our extraction protocol, conducting more than 50 formulation trials and analyzing each batch in depth.
Using high-end analytical tools like HPLC, we optimized our method to extract the broadest spectrum of compounds. This work laid the foundation for an ongoing scientific thesis, positioning Polyextract at the forefront of research in the field.
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Extraction
To capture all active compounds, we apply up to 5 extraction techniques per mushroom, tailored by species and compound profile.
Each method is optimized individually, then recombined to ensure molecular stability and bioavailability. This multi-step approach makes our extraction process unique in the industry, built not on assumption, but on data.
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Assimilation
Our extract allows faster, more efficient absorption. This is thanks to our liquid formulation, which bypasses the digestive breakdown required by capsules or powders.
Think of it as a pre-digested supplement. When active compounds are pre-dissolved, your body works less and absorbs more. Some compounds have shown up to 185× better absorption in liquid form.
Questions ? We're here to help you.
How do I take Lion's Mane Extract ?
Take x1 full dropper pipette (1 mL) per day.
Mix it into a glass of water or any other cold liquid.You can also take it directly under the tongue.
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For best results:
- Take consistently. Lion's Mane works best when used daily over time.
- Avoid mixing with hot liquids, as heat may affect the stability of some sensitive compounds.
- Take at the same time each day, ideally within one hour of your usual wake-up and wind-down times to stay aligned with your circadian rhythm.
- During high-demand periods (mental or physical), you may temporarily increase to 30–40 drops per day (1.5 to 2 full pipettes), split between morning and evening.
- Start with 5 drops in the morning and 5 in the evening. Then, Increase daily by +2 drops total (add 1 drop to each dose) until you reach 20 drops per day by day 6 (10 in the morning, 10 in the evening).
- Always Shake well before use.
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x1 dropper pipette = 1 mL = 0.0338 oz. ≈ x20 dropps
Do not exceed 50 drops per day.
Do not use if under 18 years old, or if you are a pregnant/breastfeeding women.
What’s Inside the Lion's Mane Extract ?
Organic Farmed Lion's Mane - Hericium erinaceus - (Liquid Extract)
- 100% Organically Grown - Certified by Ecocert (EU Agriculture)
- Fruiting Body (100%)
- Mushroom Origin: Belgium (BE)
Other Ingredients: Purified Water, Food Grade Organic Ethanol (20-24%)*
And nothing else !
*Note: Ethanol is used as a solvent to extract and stabilize bioactive compounds and enhance product bioavailability.
Why should I choose Polyextract Supplement ?
Lion’s Mane is traditionally used by individuals seeking mental clarity, long-term focus, and cognitive balance. It's often chosen as part of a daily routine by those who value natural compounds with a growing body of scientific interest behind them.
Taking Lion’s Mane in a liquid, bioavailable form, like the one we offer at Polyextract, provides access to the mushroom’s full spectrum of natural compounds without the need to source or prepare it fresh.
Our triple-extraction method captures and stabilizes key actives such as hericenones and polysaccharides, ensuring they’re delivered in a form your body can absorb efficiently.
Compared to raw mushroom or standard powders, our extract offers superior absorption and seamless integration into your daily routine.
When will I feel something?
Everyone responds differently. Some users report feeling more focused and mentally clear within 10 to 30 days of consistent use, but Lion’s Mane isn’t about instant effects.
Like many adaptogens and functional compounds, it works best when taken daily over time. The most noticeable shifts may be subtle at first (like improved mental presence or reduced mental fatigue) but its deeper value lies in long-term cognitive support and daily rhythm.
Even if you don’t "feel" something immediately, that doesn’t mean it isn’t working.
The bioactive compounds are doing their job in the background, supporting processes you may not consciously detect but that accumulate over time.
What does Lion's Mane Mushroom extract do?
Polyextract’s Lion’s Mane extract contains a broad spectrum of naturally occurring compounds (such as hericenones, erinacines, and polysaccharides) found in fresh, organic fruiting bodies.
These compounds have been increasingly studied for their potential roles in areas like mental clarity, focus, cognitive aging, neurotrophic and nootropic activities.
You can explore the research associated with these compounds in our Scientific Reference Library.
Can I take Lion's Mane extract with other supplements or medications?
Yes, many people include Lion’s Mane in their broader supplement routine, and there are no known contraindications with other medications.
If you’re combining it with other products, we recommend spacing doses throughout the day and observing how your body responds.
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As with any supplement, it’s best to consult your physician before starting, especially if you’re on prescription medication or managing a health condition.
Our herbal and fungal extracts are highly concentrated, far beyond what you'd use in cooking. While there’s no official contraindication, we advise individuals with epilepsy to consult their healthcare provider before using Lion’s Mane, as it may interact with the Nerve Growth Factor (NGF) pathway.
Some users also report increased mental clarity and alertness, especially when taking Lion’s Mane in the evening, which might delay sleep in sensitive individuals. We recommend taking it in the morning or early afternoon when testing your sensitivity.
Who It’s For ?
Lion’s Mane can be a valuable addition to your wellness routine, especially if:
You’re 50+ and looking to support cognitive well being as you age.
You’re 20+ and seeking to maintain memory , mental clarity and concentration through natural routines.
